Biochem/physiol actions safrole is a naturally-occurring genotoxic compound found in sassafras root and areca (betel) quid it is a hepatocarcinogen, and safrole-dna adducts have also been seen in oral cancers of areca users. Mdma / mda comprehensive safrole faq safrole from plants safrole - synthesis & reactions (beilstein crossfire search) distillation of safrole determination of essential oil safrole content. Proposed synthesis of safrole from phenol if anyone gets really bored here is a nice little project to undertake i am mainly posting it to show just how easy it could be to avoid the commercial sources of precursors, if neccessary or simply as just a prudent step.
Safrole and sassafras oil are used in the illicit manufacture of mdma the drug enforcement administration (dea) is issuing this notice to inform individuals and businesses handling safrole and essential oils rich in safrole, such as sassafras oil, brown camphor. The best safrole tends to come from vietnam in the form of natural oils also, if you can get it, you can usually get 95-100% pure safrole oil from north korea via china always work in a well ventilated area, especially when working with solvents, or if you end up using the nitromethane method detailed below, with that. Yes you could use safrole oil to make mdma, but you would also need other supplies such as solvents, reagents, lab equipment etc and probably a low university-level education in chemistry/organic chemistry (first year maybe. Reaction schemes for the synthesis of safrole, pmk of natural and petrochemical origin 23 instrumental carbon-14 analysis was done by liquid scintillation counting (lsc.
The expertise needed in mdma production varies according to the route of synthesis clandestine production is easiest starting with pmk otherwise, mdma can be synthesized from piperonal, isosafrole, or safrole. Safrole is formerly used as a food flavour it is a precursor in the synthesis of the insecticide synergist piperonyl butoxide and the recreational drug mdma (ecstacy) safrole is a natural plant constituent, found in oil of sassafras and certain other essential oils. Safrole is a phenylpropeneit is a colorless or slightly yellow oily liquid typically extracted from the root-bark or the fruit of sassafras plants in the form of sassafras oil (although commercially available culinary sassafras oil is usually devoid of safrole due to a rule passed by the fda in 1960), or is synthesized from catechol or other related methylenedioxy compounds.
Safrole is not the only precursor to mdma there are many i believe that you can even use saffron in a large enough amount but i don't think it is cost effective. Chemical synthesis of mdma - 3,4-methylenedioxy-n-methylamphetamine the four main precursors used to manufacture mdma are: safrole, isosafrol, piperonal and 3,4-methylenedioxyphenyl-2-propanone. Distillation: of natural oil to obtain pure safrole a comprehensive description of this step by chromic set up for a vacuum distillation like on page 53 of zubrick.
Synthesis of mdma and related analogs from safrole detection in body fluids mdma and mda may be quantitated in blood, plasma or urine to monitor for use, confirm a diagnosis of poisoning or assist in the forensic investigation of a traffic or other criminal violation or a sudden death. Advisories to the public the drug enforcement administration (dea) is issuing this notice to inform individuals and businesses handling safrole and essential oils rich in safrole, such as sassafras oil, brown camphor oil 1070, also referred to as chinese sassafras oil, that they are sometimes used in the manufacture of mdma. Mdma is manufactured by safrole, a liquid extract from sassafras trees the most popular way to convert safrole into mdma is by synthesizing the 3,4-methylenedioxyphenyl-2-propanone (mdp2p) intermediate via the wacker process or by isomerizing safrole into isosafrole by a strong base. Mdma mdma and the effects the drug has on a person sarah cedillo tusculum college mdma (methylenedioxy-methamphetamine), also known as ecstasy, is a synthetic drug that has similarities to both the stimulant amphetamine and the hallucinogen mescaline (baselt, 2011.
It is over a 20 step synthesis and to my knowledge it takes a full day or two because there isn't a very stable intermediate but mdma you can produce the mdp2p and that can be kept for a long time with no decomposition, and the mdma can be produced in smaller amounts. Safrole is a phenylpropene it is a colorless or slightly yellow oily liquid typically extracted from the root-bark or the fruit of sassafras plants in the form of sassafras oil (although commercially available culinary sassafras oil is usually devoid of safrole due to a rule passed by the fda in 1960), or is synthesized from catechol or other related methylenedioxy compounds.
Possession of synthesis-worthy amounts of safrole may present a very serious legal problem, as it is used by some to illegally manufacture mdma(ecstasy) a permit is required to exchange safrole in any significant amount. Piperonal, mdp2p, safrole, benzodioxole, the catechol analogues of all these there are a lot of them which could be effective if you are producing mdma for anything other than the fun of it then you are probably losing money. On the note that safrole is an oil, a while ago i had access to a yellow to brown wet mdma crystals, there were clear crystals formed but when it came in a baggie, it was also wet and gluggy however leaving it out for a small while to let it dry would let you crush the crystals into a fine white powder.